Important Safety Information

Please read before starting treatment.

This summary does not include everything about these medications. Talk with your provider and read the medication guide that comes with your prescription.

GLP-1 medications (semaglutide, tirzepatide)

Boxed warning — risk of thyroid C-cell tumors. In studies in rodents, these medications caused thyroid C-cell tumors, including cancer. It is not known whether they cause these tumors in people. Do not use them if you or a family member have ever had medullary thyroid carcinoma (MTC), or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your provider if you notice a lump or swelling in your neck, trouble swallowing, hoarseness, or shortness of breath.

Do not use if you:

  • Have a personal or family history of MTC or have MEN 2
  • Have had a serious allergic reaction to the medication or any of its ingredients
  • Are pregnant or planning to become pregnant

Possible serious side effects include:

  • Inflammation of the pancreas (pancreatitis) — severe stomach pain that may spread to your back
  • Gallbladder problems, including gallstones
  • Low blood sugar, especially with insulin or a sulfonylurea
  • Kidney problems, which may worsen with dehydration from vomiting or diarrhea
  • Serious allergic reactions
  • Changes in vision in people with type 2 diabetes and diabetic retinopathy
  • Increased heart rate
  • Depression or thoughts of suicide — tell your provider about any changes in mood
  • Food or liquid getting into the lungs during anesthesia or deep sedation — tell any surgical team you take this medication

Most common side effects: nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, and fatigue. Tell your provider about any side effect that bothers you or does not go away. Birth control pills may be less effective with tirzepatide; ask your provider about backup contraception.

Compounded medications

Some medications we prescribe may be prepared by a state-licensed compounding pharmacy. Compounded medications are not FDA-approved, and the FDA does not review them for safety, effectiveness, or quality.

Peptides and regenerative therapies

Some peptide and regenerative therapies are prescribed off-label or are compounded and are not FDA-approved for the uses described. Your provider will review the evidence, risks, and alternatives with you.

Growth-hormone–releasing peptides may cause injection-site reactions, flushing, headache, fluid retention, joint pain, or changes in blood sugar. They may not be appropriate if you have active cancer, are pregnant, or have certain endocrine conditions. IV and injection therapies carry risks such as bruising, infection, or allergic reaction.

Reporting side effects

Call us at the number below with any concerns. You may also report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088. If you have a medical emergency, call 911.

Content on this site is for general information only and is not medical advice. Do not start, stop, or change any medication without talking to a licensed provider.